Browser extensions are convenient and they run inside the most attacked software on your computer. Frame moves signing out to a native application: websites connect to it through a local provider, and every connection, chain switch and signature is approved in an interface that no web page can render or manipulate.
Permissions and control
Frame lets you grant permissions per origin, choose which account a given site sees, and route requests through your own RPC endpoints rather than a default provider that logs your activity. For privacy-conscious users, that last option matters more than most wallet features — the default RPC in most wallets sees every request you make.
Hardware integration
Among the best in the category, with direct support for Ledger, Trezor and Lattice1 without going through an extension. For anyone whose keys live on hardware, Frame is a cleaner path than a browser extension acting as an intermediary.
The trade-off
It is a small project. Development moves slowly, new chains and standards arrive later than in mainstream wallets, and support is community-based. Setup requires more effort than installing an extension.
Who should use it
Desktop users with hardware wallets who want to shrink the browser's role in their signing flow, and privacy-conscious users who want to control their own RPC endpoints.